Ruban Y. Placenta disfunction after auxiliary genesial technologies: prognostication, tactic of conduct of pregnancy and delivery.

Dissertation work is devoted to the decline of frequency of perinatal pathology for women after auxiliary genesial technologies on the basis of establishment of new aspects of pathogeny of placenta disfunction, and also improvement and introduction of algorithm of prognostic and treatment-and-prophylactic measures. The nosotropic links of placenta disfunction are set for women after auxiliary genesial technologies, which consist in nosotropic unity of clinical motion of pregnancy, change of parameters of hormonal type, hemostasis and ultrasonic research. By basic parameters, between which found out strong cross-correlation intercommunications were volume of chorion, systolic-diastolic relation and index of resistance in a right uterine artery, local hypertone and removing layer by layer of chorion, discovered at ultrasonic research, level of estradiol, amount of thrombocytes clinical displays of threat of abortion: pain syndrome and bloody excretions. It is rotined that women after auxiliary genesial technologies have the early beginning the features of placenta disfunction (21-22 weeks pregnancies); high-frequency of combination of placenta disfunction and delay of development of fetus (>50%); in a II trimester an enhanceable level (>30%) of the premature ripening of placenta is on a background violations of uteroplacental blood stream; in a III trimester the shortage of water and violation of placenta-fetus blood stream takes place additionally; interplacental by-passing of blood (varices of vasoganglion of chorionic plate of placenta disk); the "united" anomalies of development of dung (>50%) were accompanied by limitation of him morpho-functional lability and by absence of adequate compensatory-adaptive reactions, that was clinically expressed in decompensation. Intercommunication is presented between the volume of chorion and indexes of uterine blood stream; found out strong correlations of values of estradiol with ultrasonic descriptions, local hypertone, removing layer by layer of chorion, by the level of thrombocytes by the clinical displays of threat of abortion (pain syndrome, removing layer by layer of chorion).