Verveha B. Features of the development of acute generalized peritonitis on the background of diabetes mellitus and its pharmaco-correction

Object - mechanisms of development of acute peritonitis under conditions of streptozotocin-induced diabetes mellitus and its correction with the drug "Armadin"; goal - to elucidate the mechanisms of development of acute peritonitis on the background of streptozotocin-induced diabetes mellitus and to assess the therapeutic effect of the drug "Armadin" on the formation of metabolic disorders in this combined pathology; methods - - experimental, biochemical; immunological; enzyme-linked immunosorbent assays; histological; microbiological; mathematical; results - consistent activation of free radical oxidation of lipids and proteins against the background of suppression of antioxidant activity, increasing the severity of endogenous intoxication syndrome, impaired antitoxic and protein-synthesizing function of the liver depending on the stage of peritonitis in concomitant The study of the small intestine microbiome was conducted for the first time and it was found that the progression of the inflammatory process of the peritoneum on the background of hyperglycemia is accompanied by increased associations of microorganisms, among which Enterobacter aerogenes, Bacteroides spp. and fungi of the genus Candida at the same time with a decrease in the number of Escherichia coli compared with animals with acute peritonitis without concomitant pathology; the use of monitoring the chronological dynamics of morphological changes in organ structures in acute peritoneal inflammation on the background of streptozotocin-induced diabetes mellitus revealed the development of multiorgan failure, which is determined by inflammatory-dystrophic and degenerative-necrotic changes in the lungs, heart, intestines, liver, liver, liver and liver; It is proved that the use of the drug "Armadin" (ethylmethylhydroxypyridine succinate) in experimental acute peritonitis in combination with diabetes contributes to a significant reduction in the processes of free radical oxidation of lipids and proteins, restoration of functional activity of enzymatic enzymatic and fermentative enzymes. endogenous intoxication syndrome, has a positive effect on the activity of hepatic transaminases and protein-synthesizing function of the liver.