Pidvalna U. Morphometric characteristics of the ascending aorta and coronary artery ostia depending on anthropometric parameters (in vivo study)

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0523U100234

Thesis Registration Form

0523U100234.pdf

Applicant for

Specialization

  • 14.03.01 - Нормальна анатомія

15-12-2023

Specialized Academic Board

Д 58.601.01

Ternopil National Medical University named after I. Gorbachevsky of the Ministry of Health of Ukraine

Essay

The dissertation is devoted to establishing patterns of changes in computed tomographic (CT) morphometric parameters of the ascending aorta and coronary artery ostia in people of the second period of adulthood (36-60 years for men, 36-55 years for women): practically healthy, with Marfan syndrome, with atherosclerotic lesions of the coronary arteries, with aortic annulus and leaflets calcification depending on the anthropometric indicators, as well as the relationships between them, with the development of regression models of normative X-ray parameters of the aortic sinuses and the coronary artery ostia. A comprehensive X-ray morphometric study of the ascending aorta and coronary artery ostia was carried out in people in the second period of adulthood among practically healthy people, with congenital defects and structural changes of the studied structures. Significantly higher CT indicators of the height of the aortic sinuses were established in people of the second period of adulthood with Marfan syndrome, compared with practically healthy ones. It has been verified that most CT morphometric indicators in men are lower in groups of men with structural changes in the aortic valve or with atherosclerotic lesions of the coronary arteries. In practically healthy people of the second period of adulthood, significant dependences of body length on the height of all aortic sinuses among men and only on the height of the left aortic sinus among women were proven. The modeling of parameters of the height parameters of the aortic sinuses and coronary arteries depending on the anthropometric parameters was carried out, and the complex influence of the anthropometric parameters on the parameters of the studied structures was established. The models included: body weight in a group of practically healthy men in the second period of adulthood; total body dimensions and indicators of body mass index and body surface area for groups of both sexes in Marfan syndrome. For clarity of work of logistic models, they were tested by calculating the predicted values of the parameters of the studied structures for individuals from the studied groups with different anthropometric parameters. The specifics of the relationship between angiographic morphometric parameters of coronary artery ostia and anthropometric indicators in elderly people with established manifestations of sexual dimorphism have been established. For the first time in the field of theoretical medicine of Ukraine, intravascular ultrasound examination with in vivo determination of morphometric parameters of coronary artery ostia was used. The specifics of the relationship between sonographic morphometric parameters of coronary artery ostia in elderly people of both sexes and anthropometric indicators were verified.

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Research papers

1. Pidvalna, U., Beshley, D., Mateshuk-Vatseba, L., Averchuk, V., & Kulyk, L. (2020). Anatomy of aortic dissection in the patient with Marfan syndrome who underwent surgery: a case report. Proceeding of the Shevchenko Scientific Society. Medical Sciences, 59(1), 116–124. doi: 10.25040/ntsh2020.01.12. (SCOPUS, Q4)

2. Бешлей, Д., Дудек, Д., Войдила, Р., Підвальна, У., Аверчук, В., & Кулик, Л. (2020). Інноваційна кардіологія та кардіохірургія у Львові. Праці НТШ. Медичні науки, 62(2), 143–149. doi: 10.25040/ntsh2020.02.16. (SCOPUS, Q4)

3. Pidvalna, U., Mateshuk-Vatseba, L., Beshley, D., & Kolishetska, M. (2021). Anatomy of the Aortic Root and the Coronary Ostia: CT Evaluation. J Morphol Sci, 38, 195–200. doi: 10.51929/jms.38.35.2021. (SCOPUS, Q4)

4. Pidvalna, U., Mirchuk, M., Voitovych, A., & Beshley, D. (2021). Anatomy of the retrograde type A aortic dissection after endovascular repair of type B aortic dissection: a case report. Heart, Vessels and Transplantation, 5(3), 135–143. doi: 10.24969/hvt.2021.262. (SCOPUS, Q4)

5. Pidvalna, U., Beshley, D., Mirchuk, M., & Mateshuk-Vatseba, L. (2021). Normal values of coronary arteries branching height in women. Reports of Morphology, 27(4), 41–46. doi: 10.31393/morphology-journal-2021-27(4)-06.

6. Підвальна, У.Є., Бешлей, Д.М., Матешук-Вацеба, Л.Р. (2021). Морфометрія відходження вінцевих артерій у чоловіків в нормі. Морфологія, 15(4), 74–80. doi: 10.26641/1997-9665.2021.4.76-80.

7. Pidvalna, U., Mateshuk-Vatseba, L., & Beshley, D. (2022). CT assessment of the height of the coronary arteries orifice location and the height of the aortic sinuses in women with structural changes in the coronary arteries. Reports of Morphology, 26(1), 27–33. doi: 10.31393/morphology-journal-2022-28(1)-04.

8. Pidvalna, U., Mateshuk-Vatseba, L., & Beshley, D. (2022). Morphometric analysis and the model for predicting the height of the sinuses of valsalva depending on anthropometric and age parameters in men with severe aortic stenosis. J Morphol Sci, 39, 200–207. doi: 10.51929/jms.39.200.2022. (SCOPUS, Q4)

9. Pidvalna, U., Mirchuk, M., Mateshuk-Vatseba, L., & Beshley, D. (2022). Morphometric characteristics of the aorta and heart in situs inversus totalis. Anat Cell Biol, 55, 259–263. doi: 10.5115/acb.21.252. (SCOPUS, Q2, WEB OF SCIENCE)

10. Pidvalna, U.Yе. (2022). Morphometric analysis of the aortic root in women with aortic stenosis. Bulletin of problems biology and medicine, 2(165), 136–146. doi: 10.29254/2077-4214-2022-2-2-165-136-146.

11. Pidvalna, U. (2022). Correlation between aortic root dimensions and biometric indicators in coronary heart disease. Reports of Morphology, 28(3), 14–20. doi: 10.31393/morphology-journal-2022-28(3)-02.

12. Pidvalna, U., Lonchyna, V., Beshley, D., & Mateshuk-Vatseba, L. (2022). The height of the sinuses of Valsalva depending on anthropometric data among Ukrainian population. Eur J Anat, 26(5), 487–494. doi: 10.52083/IYMG4367. (SCOPUS, Q4, WEB OF SCIENCE)

13. Pidvalna, U., Mangov, A., & Mirchuk M. (2022). Heterotaxy syndrome in Covid-19 patient with pulmonary embolism and aortic aneurysm: a rare accidental combination (radiological assessment). Problem of radiation and radiobiology, 27, 495–503. doi: 10.33145/2304-8336-2022-27-495-503. (SCOPUS, Q4)

14. Підвальна, У. (2022). Морфометрія вічок вінцевих артерій у жінок: ангіографічне дослідження. Вісник проблем біології і медицини, 3(166), 426–435. doi: 10.29254/2077-4214-2022-3-166-426-435.

15. Підвальна, У. (2022). Геометрія вічок вінцевих артерій: внутрішньосудинне ультразвукове дослідження (in vivo). Морфологія, 16(3), 91–95. doi: 10.26641/1997-9665.2022.3.91-95.

16. Pidvalna, U., Mateshuk-Vatseba, L., Beshley, D., Harapko, T., & Hresko, N. (2022). Relationship between anthropometric indicators and coronary ostia dimensions in men. World of Medicine and Biology, 4(82), 143–147. doi: 10.26724/2079-8334-2022-4-82-143-147. WEB OF SCIENCE

17. Підвальна, У. (2022). Оцінка параметрів вічок вінцевих артерій у чоловіків: Внутрішньосудинне ультразвукове дослідження. Art of Medicine, 24(4), 136–141. doi: 10.21802/artm.2022.4.24.136.

18. Pidvalna, U., Beshley, D., & Mateshuk-Vatseba L. (2023). Association between the sinus of Valsalva height and biometric parameters in patients with Marfan syndrome associated with aortic root aneurysm. Eur J Anat, 27(2), 181–189. doi: 10.52083/POQB7776. (SCOPUS, Q4, WEB OF SCIENCE)

19. Pidvalna, U.Y. (2023). Modeling of Valsalva sinuses and coronary artery ostia height parameters, depending on age-anthropometric indicators in healthy men based on computed tomography. Reports of Morphology, 29(1), 9–14. doi: 10.31393/morphology-journal-2023-29(1)-02.

20. Pidvalna, U., Beshley, D., Avramenko, I., & Mateshuk-Vatseba, L. (2023). Morphometric and morphological assessment of coronary arteries with intravascular ultrasound. Wiad Lek, 76(2), 305–310. doi: 10.36740/WLek202302109. (SCOPUS, Q4)

21. Pidvalna, U., & Beshley, D. (2022). Senile calcific aortic valve stenosis: modern interventions in Ukraine. Anti Aging East Eur, 1(2), 123–128. doi: 10.56543/aaeeu.2022.1.2.07.

22. Pidvalna, U., Bodak, P., Vyshynska, S., & Beshley, D. (2023). Successful myocardial revascularization in a 92-year-old female patient: a case report. Anti Aging East Eur, 2(1), 59–62. doi: 10.56543/aaeeu.2023.2.1.11.

23. Підвальна, У., & Матешук-Вацеба, Л. (2020). Цибулина аорти: анатомія, гістологія, топографічна анатомія. Вісник проблем біології і медицини, 4(158), 39–43. doi: 10.29254/2077-4214-2020-4-158-39-43.

24. Підвальна, У, & Матешук-Вацеба, Л. (2020). Вінцеві артерії: норма, варіанти, аномалії (огляд літератури). Вісник Вінницького національного медичного університету, 4(3), 524–529. doi: 10.31393/reports-vnmedical-2020-24(3)-25

25. Pidvalna, U., Plyatsko, R., & Lonchyna, V. (2021). Ivan Puluj and the discovery of X-rays. Proc Shevchenko Sci Soc Med Sci, 64(1), 180–190. doi: 10.25040/ntsh2021.01.18. (SCOPUS, Q4)

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Files

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Дисертація Підвальної У-Є.pdf

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