Tkachuk R. The Course of Pregnancy and Labor Stage in Women with Autonomic Dysfunction, Prevention of Obstetric and Perinatal Complications

The dissertation focuses on reducing the frequency of obstetric and perinatal complications by establishing new links in their pathogenesis based on the study of pregnancy and labour course in pregnant women with autonomic dysfunction, as well as correction of identified violations. In some cases, autonomic regulation allows to correct a pathological or pre-pathological condition, and in other cases, it becomes a factor of pathogenesis. Ultimately, the autonomic balance and the premorbid background of physiological regulations of the maternal body are critical conditions for normal fetal development, and in some cases, they can serve as pathogenetic factors of gestational pathology. In modern physiology, much attention is paid to the diagnosis of the functional state of certain systems, which could be used to assess the state of the whole body and its ability to adaptation. As a result of numerous physiological and clinical studies, the possibility of using measuring data of functional indicators of the cardiovascular system as an indicator of adaptive responses of the whole body and an indicator of the risk of diseases developing has been proved. The use of this approach is possible because the circulatory system serves as a link between all organs and systems of the body, between "control centres" and "control elements". Mathematical computer analysis of heart rate variability (cardiointervalography - CIG) is a modern methodological approach in assessing the body's adaptation to the environment, the stress adaptation mechanisms, and the functional condition of the autonomic nervous system. The presence of dysfunction of the autonomic nervous system in pregnant women should be regarded as a serious pathological condition, which requires the use of the advanced diagnostic methods, including heart rate variability, the correct choice of pregnancy management tactics in order to prevent gestational, labour and post-partum complications. Taking into account the regulatory role of the ANS during the gestation process, labour and neonatal adaptation, it is more promising to study the early criteria for the diagnosis of autonomic disorders and prevention of perinatal complications.