Object: economic mechanism of efficient activity regulation for machinery enterprises. Aim: substantiation of theoretical and methodological provisions and scientific-practical recommendations as for improvement economic mechanism of efficient activity regulation for machinery enterprises. Methods of research: dialectical cognition method, induction and deduction method, theoretical comparison method, observation method, grouping method, abstract-logical method, causal relationship method, description method, conceptic method, formalization method, dialectical method, systematization method, generalization method, graphical method. There were improved: classification of methods of regulation of industrial enterprises, which take into account objects, subjects, content, purpose, nature, time of influence, method of making management decisions; methodological approach to assessing the effectiveness of the functioning of the economic mechanism of the enterprise by using the criteria of Fisher, Student, which allow to predict net income from the sale of products of mechanical engineering enterprises; methodological approach to the diagnosis of the effectiveness of the economic mechanism of mechanical engineering enterprises, which provides for the assessment of internal and external factors of influence, that allows you to measure risk-forming factors; methodological approach to assessing the effectiveness of mechanical engineering enterprises on the basis of the integral indicator due to the weighted average cost of capital, taking into account changes in the internal environment of the enterprise; methodical approach to determining the impact of business activity indicators on profitability indicators using a matrix approach, which allows regulating profitability and profitability indicators; has acquired further development: classification of properties of information support of the enterprise according to the criteria of completeness, form, reliability, value, adequacy, relevance, timeliness, clarity, utility, subjectivity, quality, representativeness, content, sustainability of information; methodological approach to comprehensive and integrated evaluation of the efficiency of enterprises under the influence of liquidity components, financial stability, business activity, profitability by ranking influential indicators, which allows you to take into account the ranks of individual indicators; the essence of the concept of an economic mechanism; the essence of the concept of efficiency of activity. Field of use: mechanical engineering enterprises.