The dissertation work is devoted to the complex comparative pharmacognostic research of herb and seeds of Camelinasativa and Camelinamicrocarpa, to the design of herbal medicines, to the development of methods of quality control on medicinal plant raw materials and the received medicinal products of plant origin. Rutin and chlorogenic acid have been identified in the grass of both species. Rutine was identified in the seeds of both species. The presence of these individual compounds was confirmed by HPLC and it was found them the content. The amount of flavonoids, hydroxycinnamic acids and polyphenolic compounds wascalculated by spectrophotometric method. As a result of the study of the amino acid composition of both species raw materials, 17 amino acids were identified. The following amino acids were found in the largest amount in C. sativa herb: glutamic, asparagine, proline, leucine. In C.sativa seeds, the predominant amino acids were: glutamine, asparagine, arginine, lysine. In C. microcarpa herb, the following amino acids were revealed in the largest amount: glutamic, aspartic, proline, arginine. In the seeds of C. microcarpa, the following amino acids were found in the largest amounts: glutamic, aspartic, glycine, arginine. The highest content of the amino acids sum was determined in the seeds of C.sativa. The monomeric composition of polysaccharide fractions was investigated with TLC. Galactose, glucose and arabinose were detected in the hydrolysates of these fractions of C. sativa herb and seeds. The presence of galactose, glucose, arabinose and xylose was found in C.microcarpa herb and seeds.Polysaccharide complexes were calculated with spectrophotometric method. The qualitative composition of free organic acids in the raw materials of both species was determined by TLC. The presence of oxalic, malic, ascorbic and benzoic acids was determined in C.sativa herb. Oxalic, malic and benzoic acids were found in C.microcarpa herb. The presence of oxalic and benzoic acids was registered in the seeds of both species.Quantitative determination of the amount of free organic acids was performed with titrimetric method. The content of fatty acids (FA) in the raw materials of the studied species was investigated by the GC-MS method. Thus, the content of FA in the C.sativa herb is 2.04%. The content of FA in the C.sativa seeds is 40,31%. The content of FA in the C.microcarpa herb is 3.58 %. The content of FA In C.microcarpa seeds is 44.24%. It was found that linolenic, eicosenic and linoleic acids have the highest content among FAof seeds of both species. The obtained experimental data on the macro- and microelement composition of C.sativa and C.microcarpa raw materials indicate the presence of at least 19 elements. The highest total content of elements was determined in the herb of C.microcarpa. The morphological features of both species of the genus CamelinaCrantzherb were determined. Common macroscopic features include: leaves are sessile, alternate, pubescent, oblong-lanceolate with an arrow-shaped base. Besides, both plants have distinctive macroscopic features. The leaf of C.sativa is larger in size and has a serrated edge. The edge of C.microcarpaleaf is whole. The fruit differs in shape and size: in the C.sativa,it is larger and inverted-ovate; in C.microcarpa, it is a little smaller and pear-shaped. The seeds also differ in size and color: in C.sativa,they are bigger and yellow-orange. In C.microcarpa, seeds are smaller and dark brown. Common microscopic features are: dorso-ventral leaf blade, amphistomatic. Respiratory apparatus of the anisocyte type, there are numerous simple hairs. The vascular-fibrous bundle of the petiole is collateral. Stem rounded, densely pubescent with simple hairs, in the axial cylinder vascular-fibrous bundles, the type of structure is transitional. In the petals, the vascular-fibrous bundle is represented by spiral vessels. As for the distinctive microscopic features, we can say that there are almost no differences. The projects of quality control methods (QCM) for herb of both species has been developed. For pharmacological studies, a thick extract of C.sativa herb (ECS) and oil of C.sativaseeds was obtained.Rutin and chlorogenic acid were confirmed by TCL and HPLC in a thick extract of C.sativa. The quantitative content of the sum of flavonoids, hydroxycinnamic acids,polyphenolic compoundswas determined by spectrophotometric method. The parameters of standardization of C.sativa herb thick extract were studied. The projects of quality control methods for thick extract has been developed. Acute toxicity of the obtained extracts was determined (class V toxicity). It was found that a thick extract of herb and oil from the seeds of C.sativashow hypoglycemic activity. ECS helped to improve lipid metabolism. The antiradical activity of ECS was also investigated.
