Boiko O. Optimization of intensive therapy in patients with thoracic trauma with polytrauma

Українська версія

Thesis for the degree of Doctor of Philosophy (PhD)

State registration number

0823U100110

Applicant for

Specialization

  • 222 - Медицина

01-02-2023

Specialized Academic Board

ДФ 64.600.053

Kharkiv National Medical University

Essay

This study is based on a theoretical generalization and a new solution to an urgent scientific problem related to improving the effectiveness of treatment of patients with thoracic trauma in polytrauma based on the prevention of complications by improving intensive care methods. Patients selected for studying the clinical and pathogenetic aspects of the course of traumatic illness in patients with thoracic trauma in polytrauma were divided into 3 stratified clinical groups within a cohort clinical open prospective study depending on the content of intensive care components: in group I, intensive care was performed according to the clinical protocol for the provision of medical care for polytrauma, in group II - in addition to the main intensive care protocol, ceruloplasmin solution was prescribed in the amount of The work presents the created algorithm of medical and diagnostic tactics and improved system of predicting the outcomes of the complicated posttraumatic period, which allows to distinguish and systematize such patients by clinical groups with the same type of tactical tasks based on further study of the content of alveolar protein D and cepuloplasmin in the blood plasma of patients and makes it possible to apply a differentiated approach to intensive care in thoracic trauma with polytrauma using modern medical equipment. The practical use of the developed methods and techniques can significantly increase the effectiveness of complex intensive care in patients of this category, namely: reduce the severity of respiratory dysfunction by 30-35%, reduce the number of bed days in the intensive care unit by 3-5 days, the total duration of treatment by 10-15 days, and reduce the number of complications by almost half.

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