The thesis is devоted tо the study оf cоmmоn sоapwоrt and marigоlds, which, accоrding tо literature sоurces, are used in traditiоnal medicine as diuretics. A comprehensive pharmacognostic study of the Saponaria officinalis herb and roots and the Tagetes lucida herb, was carried out. In the studied raw materials, the presence and quantitative content of carbohydrates, carboxylic and amino acids, volatile compounds, saponins, phenolic compounds - hydroxycinnamic acids, flavonoids, tannins, along with their mineral composition, were found and determined. The polysaccharide complexes were investigated in the Saponaria officinalis herb and roots and the Tagetes lucida herb, the fractions of water-soluble polysaccharides (WPS) and pectin substances (PR) were isolated, and their monomer composition was determined. The qualitative composition was established, and the quantitative content of the sum of organic acids and the quantitative content of ascorbic acid in the raw materials of the studied species was identified and determined. For the first time, the quantitative content of individual organic acids was detected and determined by HPLC in the Saponaria officinalis herb and roots and GC/MS in Tagetes lucida herb. The fatty acid composition of lipophilic fractions of the studied raw materials was analyzed for the first time. The amino acid and elemental composition of the studied objects was determined. The qualitative composition and quantitative content of volatile compounds and saponins were studied. The quantitative content of individual substances of phenolic nature was identified and determined by HPLC method in the soapwort herb and roots and the Tagetes lucida herb: from hydroxycinnamic acids - chlorogenic, caffeic, syringic, p-coumaric, trans-ferulic, synaptic, trans-cinnamic, quinic and hydroxyphenylacetic hydroxycinnamic acids; from flavonoids in the Saponaria officinalis herb - isoquercitrin and kaempferol; in the roots - quercetin, in the Tagetes lucida herb - isoquercitrin, naringin, kaempferol, and quercetin; from the components of condensed tannins - gallocatechin and epicatechin in the Saponaria officinalis herb, in the roots - gallocatechin, in the Tagetes lucida herb - gallocatechin, epicatechin and epicatechin gallate. In the Saponaria officinalis herb and roots, 13 and 12 phenolic compounds were identified, and in the Tagetes lucida herb - 15. The morphological and anatomical features of the structure of the Saponaria officinalis herb were studied, its main diagnostic features were determined, and standardization parameters were proposed. For the first time, the numerical quality indicators of the studied raw materials were determined according to the requirements of the State Pharmacopoeia of Ukraine (SPU). The optimal conditions for obtaining thick extracts of the Saponaria officinalis herb and roots and dry extract of the Tagetes lucida herb were determined, their acute toxicity was identified, and diuretic effect was established. The nephroprotective activity of thick extracts from the herb and roots of Saponaria officinalis and the antioxidant effect of the dry extract from Tagetes lucida herb were proved in vitro.
