Momot A. Effectiveness and pathogenetic justification of laser technologies application in treatment of atrophic colpitis in postmenopausal women

This thesis deals with the evaluation of the effectiveness and pathogenetic justification of the laser technologies application in the treatment of atrophic colpitis in postmenopausal women. Atrophic colpitis is one of the leading concomitant conditions of the postmenopausal period, which has a very negative impact on the life quality of women. The available local methods of conservative treatment are not effective enough, and the appointment of systemic menopausal hormone therapy is associated with risks for many organs and systems in postmenopausal women. That is why, today, in the clinical practice of atrophic colpitis treatment, laser technologies are increasingly used, which are safer for the patient, well tolerated and do not have side effects. The aim of the thesis is to improve the quality of life of postmenopausal women with vaginal tissue atrophy through pathogenetically justified of laser therapy application. Objectives of the research: 1. To conduct a clinical and statistical analysis of medical records of postmenopausal women with atrophic colpitis. 2. To determine the features of connective tissue and micronutrient metabolism in postmenopausal women with atrophic colpitis. 3. Determine the state of colpocytological features of vaginal epitelium, vaginal biocenosis, and assess the photomicroscopic and morphometric features of the vaginal mucosa, as well as its proliferative function in postmenopausal women with atrophic colpitis. 4. To determine the features of the quality of life in postmenopausal women with atrophic colpitis. 5. To develop and pathogenetically substantiate and evaluate the effectiveness of a complex of diagnostic and therapeutic measures in postmenopausal women with vulvovaginal atrophy using laser therapy. 6. Evaluate changes in the symptoms of vulvovaginal atrophy and the effect on sexual function and relapse rate when using conservative, laser and complex therapy at the beginning, after 3 months and 12 months of treatment. The research involved 160 postmenopausal women with atrophic colpitis who depending on the chosen treatment tactics were distributed as: the main group – 55 women who received CO2-laser therapy, the comparison group – 40 women who received treatment according to the proposed treatment complex, control group – 65 women who received conservative therapy. At the second stage of the study, the results were analyzed and summarized. The duration of the study was 12 months.