Khomenko V. The latest minimally invasive technologies in the diagnosis and treatment of closed abdominal injuries

The dissertation provides a theoretical rationale and a new solution to an actual scientific task, which consists in improving the effectiveness of diagnostics and surgical care for patients with closed abdominal trauma complicated by internal bleeding, through the use of the latest mini-invasive technologies. It has been proven that the use of modern minimally invasive methods of surgical treatment of patients with closed abdominal trauma significantly improves treatment results with a significant reduction in postoperative complications and mortality. A method of early diagnosis of bleeding into the abdominal cavity using a device for early diagnosis of bleeding into the abdominal cavity, which will improve the results of treatment of patients with subcapsular hematomas with two-moment ruptures of parenchymal organs, has been proposed for the first time under the conditions of an experiment on animals. It was found that applying only a closed injury to the abdomen significantly deepens the processes of cytolysis in the body; it was found that the value of ALT and AST activity in blood serum reaches a maximum by the 3rd day of the experiment, followed by a decrease, which does not reach the control level by the 14th day. The experimental results of using 2-ethyl-6-methyl-3-hydroxypyridine succinate in animals with a closed abdominal injury and internal bleeding testify to a shift in the antioxidant-prooxidant balance towards the predominance of antioxidant mechanisms. A highly effective method of diagnosing the presence of blood in the abdominal cavity due to a two-moment rupture of a subcapsular hematoma was implemented in health care practice, which made it possible to optimize the diagnostic program and speed up the provision of highly qualified surgical care with the priority use of minimally invasive laparoscopic organ-preserving surgical interventions. Methods of surgical treatment of patients with closed abdominal trauma with damage to internal organs have been improved using modern minimally invasive technologies, namely, modification of the setting of laparoscopic ports, depending on the localization of the damaged organ.