Nowadays, water is considered not only a natural resource but also a factor having social significance, since the availability of sufficient amount of proper quality water is one of the main milestones of safe living conditions and development of a country. Most countries of the world, including Ukraine, entered the XXI century with a set of environmental, global, and regional problems. The most threatening among them are the depletion and deterioration of water resources, i.e. sources of drinking water. Today, about 1.1 billion people on Earth still do not have permanent, secure access to water supply. Insufficient water intake causes a pathological condition that is accompanied by metabolic disorders and has significant consequences for population health and working capacity.
In recent decades, there has been a high growth rate of the digestive system and endocrine system diseases, which optimize the fluid volume in the body. The main reasons for the development of these diseases are not only genetic factors but rather the lifestyle and external adverse factors, such as intoxication, radiation, gravity load and hypoxic stress, salts of heavy metals, injuries, etc., to which the pancreas is very sensitive.
The issue of morphofunctional changes in the pancreas under the influence of various exogenous factors is important for both clinicians and morphologists. Despite the significant amount of work devoted to this problem, many issues still remain debatable, in particular, the changes in the pancreatic morphology under the influence of various types of dehydration. Taking into account the abovementioned facts, we can assume that experimental and clinical studies on the different types and degrees of dehydration will help clinicians predict the course of pancreatic diseases and provide adequate treatment.
The dissertation is devoted to the study of the structural features of the pancreatic parenchyma at the macro-, micro- and ultrastructural levels under the influence of general, cellular, and extracellular dehydration of various degrees of severity, studying the effectiveness of correcting the identified structural changes in the pancreas with thiazic acid morpholinium salt.
Organometric and morphometric methods, histological and histochemical studies, electron microscopy, and statistical processing of digital data were used for the study.
Summarizing the results of using the drug morpholinium salt of thiazoic acid to restore the pancreas parenchyma in conditions of various types of severe dehydration, there is reason to believe that this medication helps to reduce the manifestations of dehydration disorders (common stasis, diapedetic hemorrhages, atrophy or destruction of pancreas cells), restores the parenchyma and the structure of the pancreas by preserving and restoring the structural and functional organization of cells, reducing the manifestations of dystrophic-destructive changes in the cells of the gland and the inclusion of compensatory-regenerative processes. The severity of these processes varies depending on the type of dehydration.
