Zhurakovska H. Healing of soft tissue wounds of the maxillofacial area, closed by various methods

Any soft tissue wounds heal with the formation of scar tissue, so the study of the processes of formation and prevention of scar formation remains relevant today. According to the latest scientific statistics, unaesthetic scars occur in 10% of the total population of the world and are characterised by a significant percentage of postoperative recurrence after their removal (Nahaychuk V.V., Shkilnyak L.I., 2017). Mechanical damage to soft tissues is an inevitable element of any surgical intervention on a living object, including humans. In response to mechanical trauma, complex neurohumoral mechanisms are triggered to eliminate wound damage, restore form and function, resulting in the formation of scar tissue of various volumes and with different properties. In recent years, the number of planned surgical interventions in the maxillofacial area has tended to increase, which, accordingly, leads to an increase in the number of people with facial scars (Melnychuk Y.M., Ogonovskyi R.Z., 2015). Based on the research conducted in the dissertation, new theoretical and practical results have been established regarding the formation of scar tissue during the closure of surgical wounds using various methods. New risk factors for the development of excessive scar tissue volume have been identified, diagnostic criteria and specific tactics for the treatment and prevention of pathological scar tissue formation have been developed. The aim of the study is to increase the effectiveness of preventive intraoperative measures against the risk of unaesthetic postoperative skin scars by applying and comparing different methods of closing surgical skin wounds in the experiment. Object of study - 96 skin flaps of Wistar rats with postoperative wounds at different stages of reparative histogenesis; 6 intact skin flaps of Wistar rats.