Yeroshenko O. Method and Means Adaptive Electrical Stimulation of Neuromuscular Structures. – Qualification scientific work as a manuscript copyright.
Thesis submitted for the degree of Doctor of Philosophy in the specialty 163 "Biomedical engineering" (16 – Chemical and bioengineering). – Kharkiv National University of Radio Electronics, Ministry of Education and Science of Ukraine, Kharkiv, 2023.
The dissertation is devoted to the current scientific and technical problem of increasing the efficiency of transcutaneous electrical stimulation of human neuromuscular structures in the process of therapeutic rehabilitation procedures based on mathematical modeling and feedback based on electromyographic studies.
The aim of the dissertation is to develop a method of adaptive electrical stimulation that takes into account the individual characteristics of the patient, as well as to improve the existing hardware and software for electrical stimulation.
The object of research is the processes of electrical stimulation of human skeletal muscles during medical therapy.
The subject of research is methods of conducting therapeutic electrostimulation procedures of neuromuscular structures, mathematical models of electrical stimulation, technical means for electrical stimulation, software and methods of processing biomedical data.
Research methods. The work uses methods of mathematical analysis, methods of mathematical modeling, methods of interval analysis, methods of nonlinear programming, methods of analysis and synthesis of elements of biotechnical systems, methods of data processing, methods of object-oriented programming, methods of analysis of biomedical signal.
The main tasks of the research:
1. Development of a method of adaptive influence of electrical stimulation during a number of sessions with the possibility of choosing individual parameters of stimuli and control of effectiveness.
2. Development of mathematical models of the dependence of stimulation intensity on the amplitude, frequency and duration of the current to determine the optimal values of the stimulus parameters.
3. Assess the adequacy of electrical stimulation models in the space of external parameters.
4. Conduct a time-frequency analysis of the electromyographic signal and determine significant indicators for making decisions about conducting therapy sessions.
5. To propose the structure of the hardware and software complex, which provides the possibility of accounting for the individual characteristics of patients and the choice of the form and parameters of stimulating effects in order to achieve a positive therapeutic effect.
The scientific novelty of the dissertation is as follows:
1. A new method of adaptive electrical stimulation of skeletal muscles is proposed, which takes into account the individual characteristics of the patient.
2. For the first time, analytical models were obtained that describe the dependence of the amplitude and force of muscle contraction on the amplitude, frequency and duration of stimulating effects.
3. For the first time, a model of the sensitivity of electrical stimulation was built, which makes it possible to evaluate the influence of individual stimulus parameters when they change simultaneously.
4. The method of assessing the adequacy of developed models in the space of external variables has been further developed, which allows controlling errors during therapy.
5. The method of feedback based on electromyographic studies has been further developed, which allows monitoring the effectiveness of the therapy process.
6. The structure of the hardware and software complex for electrical stimulation based on the proposed method has been improved.
An analytical review of the subject area by research topic was conducted, the mechanisms and choice of electrostimulation modes, the expected therapeutic effect and possible areas of application were analyzed. An overview of modern existing technical solutions of electrostimulation devices and features of electrostimulation effects, types of stimuli and the selection of their parameters was carried out, the purpose and tasks of the dissertation research were formulated.
