Kravchenko N. Dislipoproteidemia, XbaI restrictional polymorphism and structure of 3'-hypervariable region of a gene apoB.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0400U001057

Thesis Registration Form

0400U001057.pdf

Applicant for

Specialization

  • 03.00.15 - Генетика

22-03-2000

Specialized Academic Board

К 64.051.18

Essay

Is marked, that level of a cholesterol on 8 % and triglycerides on 24 % is higher at the persons with Х + Х + genotype (exon 26), a level of HDL is lowered, in comparison with homozygotes Х-Х-. Variation of a level of a cholesterol and аpоВ, caused by structure 3'-VNTR of a gene аpоВ, it has made 16 % and 35 %, accordingly. Is established unequilibrium between Х + allele and plenty of repetitions (more than 36) in 3 '-VNTR of a gene аpоВ, and X- haplotype with quantity tandem of repetitions less than 34. Phеnоtypical feature of manifestation of such combination of alleles is the hypercholesterinemia, increased level ароВ and triglycerides on a background hipo-a-cholesterinemia.

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