Lugovyj B. The antihypertensive properties of peptides are generating after proteolysis of beta-casein by lactic acid bacteria

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0401U001143

Thesis Registration Form

0401U001143.pdf

Applicant for

Specialization

  • 03.00.13 - Фізіологія людини і тварин

30-03-2001

Specialized Academic Board

К 35.051.14

Ivan Franko National University of Lviv

Essay

It have been developed the antihypertensive and cardioprotective values of the peptides that were generated after proteolysis of beta-casein from cow milk by lactococci. It was elaborated the method of differential fractionation by urea and over-purification by ion-exchange chromatography for obtain the homogeneous beta-casein. The systems for the harvesting of bacterial cells and for the proteolysis of beta-casein by lactococci and milk-clotting enzymes were developed. Oligopeptides derived after proteolysis of beta-casein by strain l12 of Lactococcus lactis subsp. lactis decreases the arterial blood pressure and reduce of cardiac hypertrophy after chronic administration into hypertensive rats.

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