Koval'chuk S. Functional and metabolic changes in myocardium of rats under adriamycin influence.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0401U002383

Thesis Registration Form

0401U002383.pdf

Applicant for

Specialization

  • 03.00.13 - Фізіологія людини і тварин

05-07-2001

Specialized Academic Board

К 35.051.14

Ivan Franko National University of Lviv

Essay

Research was done of adriamycin influence on functional activity of isolated perfused rat heart, energy metabolism parameters in cardiomyocytes mitochondria, lipid peroxidation and antioxidative activity indices in myocardium and blood as well as lactic and pyruvic acids in blood. Two types of changes in functional state of heart were revealed under influences of adriamycin. Activation of lipid peroxidation was noted in all experimental animals that received adriamycin both in mitochondria and in blood serum.

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