Belkevich N. The efficiency of charcoal adsorbent and ozonotherapy in complex treatment of community-aсquired pneumonia patients with different engenous intoxication degree.

The dissertation is devoted to the problem of improvement of efficiency of community-acquired pneumonia (CAP) patients' treatment in considerable endogenous intoxication (EI) level by usage of enterosorption and ozonotherapy in the compleх treanment. Clinical and laboratory indicies of endogenous intoxication and its' components (toxemia and endotoxicosis) were studied in 175 CAP patients as well as their relation to the changes in immunity. The reliance of EI level to the severity of the disease, it's complications (toxic shock,destruction of lung tissue) and immune resistense indicies violations was revealed. The criterions of endotoxicosis degree were worked out on the ground of explored EI parameters. The favorable influence of charcoal absorbent ''Carbovit'' was established pertaining to neutralisation of intoxication and improvement of cellular immunity while it's combination with ozonotherapy conducts improvement of humoral immunity indicdes and non-specific protection as well. Ozonotherapywas performed by infusion of isotonic saline solution photomodified by device ''Kvant-01''. It was prowed, that proposed therapeutical shemes didn't lead to activation of lipoperoxidation. The advice of enterosorption and ozonotherapy usage in the routine treatment of CAP patients with endotoxicosis in the degree of sub- and decompensation fiollowing with immunodepression was reasoned. The methods of enterosorption and ozonotherapy applying in the complex treatment of these patients were worked out.