Kuryk L. Mechanisms of adaptive capacity formation and approaches to the correction of their disorders in patients with bronchial asthma

Object of study: bronchial asthma (BA); purpose: to investigate adaptive and maladaptive changes of cardiorespiratory, hemorheological and immune systems in patients with bronchial asthma, to develop an algorithm for comprehensive diagnosis, to identify risk factors for uncontrolled course of the disease, to propose methods to prevent development and progression of pathological changes in the above system; research methods: clinical and anamnestic (analysis of medical documentation, study of anamnesis, complaints, physical examination) questionnaires, body plethysmography, bicycle ergospirometry, Holter monitoring, study of biophysical parameters of erythrocytes and serum, immunological, statistical; novelty: adaptive and maladaptive changes of respiratory, cardiovascular systems, biophysical and morphofunctional characteristics of erythrocytes and serum and immune system parameters in patients with asthma depending on the severity and control of the disease, the main and additional factors that significantly increase its reliability are determined. current; an algorithm for determining physical activity and a prognostic mathematical model of its average annual dynamics have been developed, which allows predicting the controllability of asthma and the effectiveness of treatment; maladaptive changes in the indicators of the immune system in asthma have been established, on the basis of which a scale for assessing the risk of developing an uncontrolled course of the disease has been proposed; an algorithm for predicting the uncontrolled course of asthma for practical application is proposed, taking into account its phenotype and endotype, which form the components of uncontrolled course of the disease, as well as immunopathological reactions; proven effectiveness in the complex therapy of patients with asthma drugs based on ginkgolides and bilobalides, ethylmethylhydroxyperidine succinate and a complex drug containing L-carnitine, gamma-aminobutyric acid, lysine, coenzymes of vitamin B12 and B6, which restore the functional function of the system , to prevent the development of pathological changes in it, to prevent a decrease in physical performance and to restore physical activity. Sphere of application – medicine.