Salyha N. Immunobiological status of pigs in the neonatal stage and influence on it of rybotan, thymalin and levamisol

Object the process of formation of immune and antioxidant system of pigs during stages of the early postnatal development. The purpose of research: determination of age peculiarities of cell link of immune defense forming and antioxidant defence system formation during the period of early postnatal development of piglets and also possibillity of increase of their immunological reactivity by means of immunomodulative preparations: rybotan, thymalin and levamisol. The methods of investigation and equipment: immunological, biochemical, microbiological, spectrofotometr, microscope, pH-metre. Theoretical and practical results: the optimal immonomodulator and dose of its use were defined. Thanks investigations it was determined that number of leukocytes, phagocytic activity of neytrophiles, number of lymphocytes and their subpopulations, blasttransformation of lymphocytes, glutathionperoxidase's activity increased but products of peroxide oxidation of lipids decreased as applied immunomodulators in comparison with the control. Age dynamics of the immune system formation during the period of early postnatal development were under the study. Innovation: the new data on peculiarities of cell link of immune defense forming, particularly about immunoregulative activity of T-lymphocytes of different subpopulations during the receptor and proliferative phases of immune process were received. Dependence of the immunobiological status and antioxidant protection of the organism from the immunomodulative effect of some biological active medications was ascertained. Degree of inculcation: obtained data on peculiarities of immune defense forming during the period of early postnatal development of piglets (the most critical period of piglets development) are improved in a series of lectures at cattle breeding department of the Lviv State Agrarian Universitu. The findings enlarge the overview about physiological mechanisms of immune system functions of piglets forming and correction of its transgressions by means of immunomodulators and may be used in future fundamental and applied investigations of those questions and also in a practice of national economy, medicine, in educational process. The sphere of utilization is physiology, biochemistry, veterinary, animal husbandry.