Palamarchuk O. Particularities of morphological liver changes in rats under the acetaminofen and allyl alcohol influences and in the conditions of antioxidants.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0403U001174

Thesis Registration Form

0403U001174.pdf

Applicant for

Specialization

  • 14.03.01 - Нормальна анатомія

28-03-2003

Specialized Academic Board

К 58.601.01

Essay

By combined use of histological and biochemical By combined use of histological and biochemical methods was proved, that paracetamolum mainly damages 3 and 2 zones of the acinus, amazes hepatocytes of a perivenous zone and causes the greatest changes of serumal enzymes - glutamic dehydrogenase, isocitrate dehydrogenase and enzymes of microsomal fraction of a liver - NADPH-reductase and carboxyl esterase. While the toxicity of allyl alcohol is shown by damage of periphery of lobules - this toxine amazes periportal hepatocytes and causes the greatest changes alanine aminotransferase, ?-glutamyltranspeptidase and acid phosphatase activity in the blood serum, activity of microsomal glucose-6-phosphate dehydrogenase and content of retinol in the liver. In the dissertation the morphofunctional assessment of sodium selenite, Dibunolum and mexydol protective effects and the zone specifity of their have been defined.

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