Slusarenko A. The immune reactivity of human body in different conditions of technogenic environment pollution by heavy metals.

The immune status of 84 children living in urban conditions and 58 adults on the industrial territoria was studied in connection with heavy metals content in hair. The average content of mercury, lead and cadmium in adults and children was in the range the conditioned norm, exceeding its in 2,3 and 1,2 time in children and 5,2 and 2,8 in adults consequently. The peculiarities of immune status in children of urban environment were: deficit of humoral immunity, deficit of T-cell link and the expressed increase of IgE content. The immune status of adults of industry Crimean territoria was characterized by changes of relative number T-subpopulations, production of antibodies was characterized by decreasing of IgA content and increasing CIC. The common typical sign of immune status in children and adults was the decreased relative content of NK-cells and IgA. Character of the relationships testified some stimulation of the immune system with mercury concentration increasing at early stages exposure (1-6 aged) and the immune suppression later on. Correlation between immune parameters with cadmium and lead contents was less indefinite. B-lymphocytes, CD8+, CD25+, total leukocyte amount have shown the most sensitivity to all metals. CD4+ have reacted to cadmium and mercury, a total lymphocyte amount - to mercury and lead. Comparison of correlative analysis data with deviations in immunograms showed that deficit of T- and B-cell links in children and increased number of lymphocytes in adults of middle age e was caused by the metal influence, at that time as changes of humoral link were not connected with their effect. The most significant mercury and cadmium effect on the immune status was in children of 7-11 years of age.