Bilous S. Development of composition, technology and biopharmaceutical investigations of semi-solid preparations for local action

Object - information about semi-solid preparations, biological active substances - aesulan and crotamiton, auxiliary substances, which are used in technology of semi-solid preparations, semi-solid medicinal forms with aesulan and crotamiton; the purpose - scientific foundation of composition, work out of technology and biopharmaceutical investigations of semi-solid preparations with aesulan and crotamiton; methods - direct investigation and observation, comparative analysis, technological, chemical, physic-chemical; novelty - theoretical and experimental on the bases of technological, physic-chemical and microbiological research the composition and technology of preparations for treatment fungal dieses with aesulan - domestic substance, the composition and technology of crotamiton gel for treatment infection dieses of skin with purpose prophylactic secondary infections, desensitization and removing itch have been founded, physic-chemical and rheological properties of developed preparations have been studied, influence of auxiliary substances on biohparmaceutical accessibility of aesulan and crotamiton has been investigated, methods of quality control of preparations has been worked out and stability during storage has been studied, toxicology of aesulan , aesulan oinment and crotamiton gel has been investigated, the specifically activity and safety of preparations have been established; the outcomes - the analytical normative documents and the technological regulations for production aesulan oinment and crotamiton gel at the manufacture; there are introduced - into educational process of Ternopil state medical academia named by I. Gorbachevsky, National pharmaceutical university and National university "Lviv politechnica", into industrial process of Joint-stock companes "Galichpharm" and "Ternopil pharmaceutical manufacturing"; areas - pharmacy.