Abdul-Ogly L. Developmental and structural regional peculiarities wall of the heart in ontogenesis

Object of the study: Human cardiogenesis during ontogenesis to the definitive period. Purpose of the study: establishment of conformities to the law of forming of structural heterogeneity of heart wall structure in different its departments during on-togenesis. Research methods: Preparation, serial transverse cuts of heart, morphometric researches, histological and semithin cuts painted by standard histological methods, immunohistochemical methods with CD-34, Ki-67, P-53 markers, histometric researches, statistical analysis. Practical significance: The research results will allow to deepen and extend the existent pictures of structural and forming features of human heart wall functional different areas in ontogenesis, that, in same queue, will allow to account for the features of the cardiac system diseases pathogeny and basic mechanisms of some in-nate heart-diseases origin. The described features of structural organization of cardiac wall allow to ground the selection functionally of different its areas. The human heart wall geteromorphic structure provides adequate biomechanics of abbreviation for a certain age-old period. The dynamics of cellular components changing appears a morphological basis for description of heart abbreviations biomechanics. Novelty of the obtained results: The structural features of human heart wall are set, by the choice of 14 functionally heterogeneous regional areas of heart dur-ing ontogenesis up to definitive period. The relations between the structural components of cardiac wall, stages of cellular differentiation during ontogenesis to the definitive period are set. The terms of heart auricles and ventricles wall layers forming, first and secondary interaurucle partitions and muscular and membranous parts of interventricle partitions, are specified, and also development of valvular and papillary-trabecular apparatus. Morfometric and histometrric quantitative data of cardiac wall structural components are general-ized and presented as a mathematical model. Real research complements present information about cardiogenesis on the whole. Degree of introduction: Findings inculcated in an educational process on the departments of anatomy of medical Institutes of higher of Ukraine: Lugansk medical university; Ukrainian medical Stomatology academy; Uzhorodskiy national university; Kharkov medical university; Ternopolskiy state medical university; Ivano-Francovsk medical academy; Donetsk state medical university; Zaporozhian medical university; Crimean state medical university; department of topographical anatomy and operative surgery of the Bukovinsky state medical academy. Sphere of application: medicine, cardiology.