Gortyns'ka O. Morphofunctional changes in skeleton bones under conditions of hypoxia and radiation and heavy metals salts influence (anatomy-experimental investigation)

Object of the research: Laboratory rats lumbar vertebra, hip bone and shinbone. Purpose of the research: Investigation of morphofuctional changes of skeleton bones under general hypoxia influence as well as combination of hypoxia lesion and action of small doses of ionizing radiation and heavy metals salts (chromium, zinc and lead) and triel to correct revealed changes in skeleton bones with "Calcium D3 Nikomed" medicine,. Methods of research: Osteometry, light optical and ultrastructural microscopy, morphometry of the cells of bone and cartilage tissue histological specimens, quantitative evaluation of the bones chemical composition indices, statistical treatment of numerical data. Practical significance of the obtained findings: Obtained findings could be used for morphological substantiation of morphpfunctional changes in skeleton appearance in traumatologic and orthopedic, therapeutic, cardiologic, pediatric clinics. Scientific novelty of the obtained findings: Found abnormality of the bones transversal and longitudinal growth, growth cartilage structural failure, deterioration of diaphysis spongy substance and compact substance, as well as their mineral saturation reduction and water-electrolytic composition change. Degree of introduction: The findings of our research were introduced into the teaching process at departments of human being anatomy, pathological anatomy of the higher educational establishments of Ukraine (Ivano-Frankivsk city, Simpheropil city, Ternopil city, Vinnytsya city, Chernovtsi city, Sumy city). Sphere of application: medicine, traumatology, orthopedics, therapy, cardiology.