Budko H. Morphological features of bone tissue regeneration under conditions of hypoxia and general exposure of radiation and heavy metals salts (anatomy-experimental investigation)

Object of the research:Laboratory rats regeneration shinbone. Purpose of the research: Investigation of morphological features of bone tissue regeneration under conditions of hypoxia and general exposure of radiation and heavy metals salts and triel to correct revealed changes with "Osteogenon" medicine. Methods of research: Osteometry, light optical and ultrastructural microscopy, morphometry of the cells of bone and cartilage tissue histological specimens, quantitative evaluation of the bones chemical composition indices, statistical treatment of numerical data. Practical significance of the obtained findings: Obtained findings could be used for morphological substantiation of morphological features of bone tissue regeneration in traumatologic and orthopedic, therapeutic, cardiologic, pediatric clinics. Scientific novelty of the obtained findings: It was revealed growth impairment, histological and ultra structural rebuilding, chemical composition of damaged bone in conditions of hypoxia and combinedaction of hypoxia, general exposure of radiation and heavy metals. After reparative osteogenesis negative changes correction with "Osteogenon" medication it was noted the reduction of endogenous and exogenous constituents negative influence, that, in it's turn, improves shinbone's growth values, resulting in minimization of dystrophic destructive changes in newly generated callus and accelerate the processes of reparative regeneration. Degree of introduction: The findings of our research were introduced into the teaching process at departments of human being anatomy, pathological anatomy of the higher educational establishments of Ukraine (Ivano-Frankivsk city, Simpheropil city, Ternopil city, Vinnytsya city, Chernovtsi city, Sumy city). Sphere of application: medicine, traumatology, orthopedics, therapy, cardiology.