Kovalchuk G. Physiological activity of mineral water "Naftussіa" before and after its microbe deprivation

The influence of two methods of microbe deprivation of medical water "Naftussia" - ultra-violet irradiation and ultra filtration through membrane sieve - on its physical-chemical parameters, chemical contents and physiological activity has been investigated. It has been shown, that both methods are equally effective in clearing water "Naftussia", reducing a prick - index up to a level of the sanitary norm (<3). At the same time the total contents of organic carbon decreases by 11% at the irradiation, and by 12 % at the filtration. The experiments on rats have shown that the native water "Naftussia" renders a significant choleretic, antixenobiotic, antioxidative active, reduces the injuries of the mucous membrane of the stomach, caused by stress; increases the thickness of the cortex of adrenal glands, it raises the excretion of 17-ketosteroids with urine and day and night excretion of electrolytes and azotic methabolic products. For the first time the immunomodulating effects of "Naftussia" havebeen revealed, such as the increase of the contents of lymphoide elements in blood, and is especially in splen and thymus, the increase of weight of the latter. The complex research of influence "Naftussia" on phagocytose of neutrophyles, made also for the first time, has given ambiguous results: the common contents of neutrophyles in blood increased, and phagocytic index, phagocytic number and index of killing were reduced. On the whole, both irradiation and ultra filtration don't influence essentially the physiological activity of the mineral water "Naftussia", can be considered as correct and practically equivalent methods of its microbe deprivation. At the same time, the use of UV-irradiation is more preferable technologically.