Ebrakhimi M. The role of genetic markers of hereditary susceptibility and environmental factors in development and severity to asthma

Bronchial asthma (BA) is multifactorial disorder, which influenced by interaction between genes susceptibility and environmental factors. BA is one of the most common chronic diseases in the world, with a rising prevalence particularly among the young in the western world. The main goal of dissertation was to study the role of polymorphism GSTM1 and GSTT1 genotypes and environmental factors in development and severity to asthma in Ukrainian adult population, in order to design the diagnostic algorithm in Ukraine, which let us to determine the degree of susceptibility to asthma. Using clinic-genealogical survey revealed that in closed relatives of asthmatic patients (that is in first and second-degree relatives) the risk of development of asthma 8.2 times was more than any individual in Ukrainian population. We found that there was not significant different in the frequency of GSTM1 and GSTT1 genotypes in patients with familial form and without familial form of asthma. It is found the association of agenotype GSTT1 "-" with predisposition to BА in the adult patients BA in Ukraine. We studied the influences of 65 risk factors in susceptibility to asthma, and among them it was found strong association between asthma and allergy, chronic rhinitis, professional factors and first order. On the bases of the received results, the diagnostic algorithm is designed, which let us to determine the degree of susceptibility to asthma. It is especially important in persons that pathology did not develop yet, but there is a genetic predisposition to its development.