Koshel N. Influence of the irradiation, temperature and chemical factors on the different stages of ontogenesis on life span and biological age in Drosophila melanogaster

The aim of dissertation was study of effects of some physical and chemical factors at different ontogenetic stages on the biological age and life span in Drosophila melanogaster. It has been shown that the x-irradiation on the egg stage resulted in increase of the mortality rate in the young adults, whereas irradiation on the adult stage resulted in acceleration of the aging rate. Irradiation of the young adults resulted in short-time physiological stimulation and, consequently, in deterioration (increase) of the biological age and mortality rate. The irradiation in a small dose at an egg stage resulted in ultrastructural changes in an imaginal brain cells which testify the functional activization, whereas the larger doze of an irradiation caused destructive changes similar to those developed by the aging. It has been shown that the flies sensitivity to the irradiation is decreased with age. The differences in stress-resistance between males and females were shown: males have decreased stress-resistance, but the best opportunity for achievement the hormetic effect in comparison with females. It has been shown that heat shock before irradiation resulted in better radioprotector effect that after irradiation. The administration of the chemical compounds (aluminium nitrate, aurintricarbonic acid) in doses which are non-toxic for the not-irradiated flies, may resulted in toxic effects in irradiated ones.