Rudyk O. Role of sensitivity of mitochondrial permeability transition pore opening and bax expression in the development of functional changes in heart with aging

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0406U002195

Thesis Registration Form

0406U002195.pdf

Applicant for

Specialization

  • 03.00.13 - Фізіологія людини і тварин

16-05-2006

Specialized Academic Board

Д26.198.01

Essay

The dissertation is devoted to the study of age-dependent changes of sensitivity of the mitochondrial permeability transition pore (MPTP) opening. It was shown that more pronounced injury of isolated old rat heart under ischemia and reperfusion was accompanied by the increased sensitivity of MPTP-opening to inductors. Increased sensitivity partially arises from the reduction of NO- content due to half decreasing in activity of the constitutive isoform NO-synthase. It was accompanied by the increased oxidative stress in old rat heart mitochondria and increased m-RNA bax expression in old rat heart. Melatonin prevented MPTP-opening in vitro. We demonstrated that course intraperitoneal injection of melatonin to old rats as well as intermittent hypoxic training of old animals decrease sensitivity of the MPTP-opening to inductors.

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