Object of investigation – pathology of exchange of matters. The goal of the investigation study of acid-basic balance in the organism of healthy and cows with ketosis, finding out of changes of indexes of acid-basic balance of blood and urine at the different degree of ketonuria, grounds roles of glucose in the correction of violation of АВВ at treatment of animals with ketosis. The investigation method - clinical, microscopic (red corpuscles and leucocytes), biochemical (hemoglobin, glucose, general albumen and his factions, ketosis bodies, AST, ALT, general calcium, magnesium, inorganic phosphorus ions, to potassium and sodium), indexes of acid-basic balance of blood (рН, рСО2, НСО3, ВЕ, ВЕecf, SBС, рО2, SO2, ТO2, ТСO2, A-aDO2, R1) and urine (рН, general acid-basic balance, ammonium, acids, bases, relations of bases to acids). The scientific novelty: investigational complex of indexes of acid-basic balance of blood (ВЕecf, SBС, SO2, ТO2, A-aDO2, R1), that is instrumental in more complete study ofacidosis and alkalosis in the organism of animals. On the basis of study of acid-basic balance of blood and urine at modern methodical level experimentally and in theory grounds development of metabolic acidosis at cows with ketosis. First certainly indexes of acid-basic balance of blood and urine at cows with ketosis, depending on the degree of ketonuria. Basic indexes which characterize development of metabolic acidosis are set. First in Ukraine the informing indexes of acid-basic balance of urines are studied, by which it is possible to diagnose metabolic acidosis and alkalosis, and also it is investigational cross-correlation connection between the basic indexes of ABB blood and urine in healthy ones and cows’ with ketosis. It is investigational influence of intravenous introduction of glucose on the correction of violations of acid-basic balance in the organism of cows with ketosis. Inculcated: obtained conclusions are using in scientific-research work and in lecture courses of «Clinical diagnostic» and «Veterinary therapy » in Lviv National academy of the veterinary medicine under the name of S. Z. Gzhytskyj, Belotserkovkskij State Agrarian University. Using area: Veterinary Medicine.
