Object of investigation – Plural (poliorgan) internal pathology at fattening to the sapling of cattle. The goal of investigation: research of pathogeny, diagnostics methods and prophylaxis of hepato-osteodystrophic syndrome in the sapling of cattle at the protracted bagasse fattening. The investigation method – clinical, research of blood morphological composition (erythrocytes, leukocytes, leucogramma), biochemical (hemoglobin, gematocrit size, total albumen, total calcium, nonorganic phosphorus, urea, creatynin, colloid-sedimentary tests sulem, phormalin, copper-sulfate, vitamin A, carotin, activity of the AP, АSТ, АLТ, GGT), chromatographic (determination of volatile fat acids), atomicabsorbtions spectrophotometers (copper, iron, zinc), immunopherment (25-hydroxicholecalciferol, calcitonin), hystological (liver, buds, cerebrum). The scientific novelty: the separate pathogenic mechanisms of hepato-osteodystrophic syndrome in the sapling of cattle on fattening. for the first time in Ukraine was studies. The dependence between the degree of hypeproteinemia and dysproteinemia sets, that enables to diagnose and forecast development of hepatodystrophy. The correlation dependence between the results of sulem’s test and hepato-osteodystrophic syndrome is not set , which characterizes the albumensynthetic function of hepatocytes, and activity of asparagin’s transpherase in serum blood, the increase of which is the typical sign of cytolyse membranes of hepatocytes. Comparison of the diagnostic informing of three colloid-sedimentary tests is conducted between itself and with the level of total albumen and the АSТ activity. The high informing of phormalin’s test is set for diagnostics of hepatodystrophy, indexes of which (from low- to higtplus) in 100 % cases coincide with the results of sulem’s test, when on titration is outlawed less than 1,5 мл 0,1 % reagent, and test from a copper by a sulfate. Approved different charts of prophylaxis and therapy of hepato-osteodystrophic syndrome. At first described symptomsand pathomorphological changes of cerebrum in a sapling more senior 12-monthly age at В1-hypovitaminosis. Suggested: effective methods of early diagnostics of hepato-osteodystrophic syndrome. The separate pathogenic mechanisms of hepato-osteodystrophic syndrome are set. Efficiency of separate application of oily solutions of vitamins is shown And, the D2 and Е. Obtained results of researches entered in textbooks “Veterinary clinical biochemistry” (Bila Tserkva, 2002) and “Clinical diagnostics of internal illnesses of animals” (Bila Tserkva, 2004). Inculcated: obtained results are using in scientific-research, practical work, at teaching of the objects “Clinical diagnostics”, “Veterinary clinical biochemistry” and “Internal illnesses of animals” in the Bila Tserkva state agrarian university. Using area: veterinary medicine.
