Stklanina L. Growth, structure and modeling of bones under effects of the high levels of glucocorticoids and their inhibitor at the different stages of postnatal onthogenesis (anatomy-experimental trial).

Object of the research: peculiarities of bone system and humoral environment under different extragenous factors. Purpose of the research: investigation of the growth and morphology features under impact of exogenous glucocorticoid Hydrocortizone, Dexametazone, and improvement of the correction cure by means of the Bisphosphonate “Zometa”. Methods of research: osteometry, histomorphometry, chemical bones content and quantity of its macroelement, X-ray structure and phase-elements mineral analysis, biomechanical tests, biochemical analysis of the blood and urina, statistic treatment of numerical data. Practical significance of the obtained findings: obtained data could be used for creation of the constant hypercorticoid status and worked out the mode and regiment of correction cure, depending on age. Scientific novelty of the obtained findings: combine effects of the impact by Hydrocortizone with Bisphosphonate “Zometa” allows neutralize side effects of the both drugs and permits to improve the osteogenesis process. Degree of introduction: main findings of dissertation were introduced into the teaching and scientific researches at anatomy departments in Lugansk, Dnepropetrovsk, Donetsk, Kharkov, Bukovinsk State medical Universities, Winnitsky and Ushgorodsky National State medical Universities. Sphere of application: anatomy, therapy, pediatrics, orthopedics, traumathology, oncology.