WAHIB J. The effects of statins on the lipid profile and endothelial function in patients undergoing program hemodialysis

The thesis is devoted to the questions of the primary prevention of cardiovascular disease upon to the improvement of treatment by evaluating the lipid profile, inflammatory markers, and endothelial vascular function and its correction with low-dose simvastatin in patients with end-stage renal disease, undergoing program hemodialysis. 76 patients were divided into 2 groups depending on the existence of dyslipidemia: gr.I - 33(45,83%) patients with total cholesterol > 5,2 mmol|L or LDL-C >3,5 mmol|L received Simvastatin 10 mg|daily for 6 months; gr. II - 39(59,16%) - without lipid damage received no antihyperlipidemic drug. The lipid profile, including TC, LDL-C, VLDL-C, HDL-C, TG and inflammatory markers (CRP, fibrinogen and albumin) determined in blood. Echo-Doppler data were also performed to assess the endothelial-depending vasodilation of the brachial artery during reactive hyperemia. After 6 months of therapy with Simvastatin, positive changes in the lipid profile, CRP, albumin, fibrinogen and endothelial function were significantly observed. Simvastatin has shown a good efficacy and safety for dyslipidemia correction. Moreover, Simvastatin exerts beneficial effects on inflammatory markers and endothelial vascular function in haemodialysis patients.