Jehjah S. Development of production technology for anti-inflammatory lipophilic phytocomplex and suppository on its basis

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0407U002272

Thesis Registration Form

0407U002272.pdf

Applicant for

Specialization

  • 15.00.01 - Технологія ліків, організація фармацевтичної справи та судова фармація

18-05-2007

Specialized Academic Board

Д64.605.01

Essay

The thesis is devoted to technology development for obtaining of lipophilic complex from rose hips (LCRH) and of alkaloids from Berberis roots by condensed gas extraction of these crude drugs, and also to elaboration of new anti-inflammatory herbal drug in form of rectal suppository containing LCRH. For the first time it has been offered the techniques for standartizing of dog rose hips by main biologically active substance responsible for anti inflammatory activity -galactolipid 1,2- di-octadeca- 9,12,15-trienoyl-galactosylglycerol (DOTGG). In the paper condensed gas (freon) extraction processing of rose hips and Berberis roots has been studied. Production technology of LCRH and purified sum of Berberis alkaloids has been developed. Main quality parameters of obtained batches of substances were evaluated. For the first time in Ukraine composition and technology of anti-inflammatory LCRH containing suppositories "Liporozol" have been developed. The drug provides systemic activity on the same level asreference preparation diclofenac-sodium does. Techniques for qualitative and quantitative analysis of the drug "Liporozol" have been elaborated and tested. These techniques are included into specifications for the product.

Read more

Files

Автореферат Шевченко--Автореферат.doc

Автореферат Шевченко--авторефераттитул.doc

Диссертация Шевченко--ВВЕДЕНИЕ.doc

Диссертация Шевченко--ДОДАТКИ.doc

Диссертация Шевченко--ЛИТЕРАТУРА.doc

Диссертация Шевченко--ОБЩИЕ ВЫВОДЫ.doc

Диссертация Шевченко--РАЗДЕЛ1.doc

Диссертация Шевченко--РАЗДЕЛ2.doc

Диссертация Шевченко--РАЗДЕЛ3.doc

Диссертация Шевченко--РАЗДЕЛ4.doc

Диссертация Шевченко--РАЗДЕЛ5.doc

Диссертация Шевченко--Рис 4.7.doc

Диссертация Шевченко--Таблиця 5.4.doc

Similar theses

0521U102082

Melnyk Galyna Mykolaivna

Theoretical and experimental substantiation of technology of liquid and soft dosage forms in pharmacies

0421U103929

Filipska Anna M.

Elaboration of the composition, technology and study of concentrated solutions for haemodialysis

0421U103931

Korolyov Marat V.

Comprehensive assessment and ways to improve the quality of pharmaceutical care for an unevenly distributed population (on the example of the Odesa region)

0421U103692

Maksymenko Oleksandra Volodymyrivna

Pharmacoeconomic reasoning of approaches of pharmaceutical care rationalization to patients with liver cirrhosis

0421U103691

Hordiienko Olha I.

Development of the composition, technology and research of plant-based tablets for topical application in the oral cavity