Zayachnikova T. Change of pain sensitiveness of rats under an influence of hypokinetic stress.

The thesis is devoted to research of pain sensitiveness change under an influence of hypokinetic (HK) stress in the animals during development of pain syndromes. HK stress modifies both behaviour reactions of rats at the action of pain stress and pain sensitiveness at threshold level, that testifies for a modification effect of HК on the pain sensitiveness of the animals regardless of pain irritant nature. During a period of rats adaptation to short duration of HК (1-6 days) the diminishing reactions of pain duration were marked on a background of multiplying pain threshold and endurance of pain level, duration of motive activity, renewal of correlations and cluster intercommunications between the studied behaviour display a synchronization of pain sensitiveness rhythmic processes of rats in microrange, that is an optimum for adaptive conduct development which is an evidence of cross-adaptation development in the rats organism. Multiplying reactions of pain duration, diminishing of motive activity duration, pain threshold and level of pain endurance were marked during prolonged HК (7-9 days), intercommunications between painful and unpainful behaviour display disjoining, development of desynchronization, that is related to the first stage of stress development - reactions of alarm, when hyperactivating of stress on a background of oppressing of the stress-limiting systems of the organism activity takes place.