Vyazovska O. The influence of the emotional stress on the cerebral neurodynamics and heart rate variability in rats.

The object of the study. Тhe cerebral neurodynamics and the state of the heart rate regulation systems in rats. The aim of the study. Investigation of the state of the cerebral neurodynamics using Kolmogorov-Sinay entropy (KSe) of the EEG signal and quantitative estimation of the tone of heart rate regulation systems under acute and chronic emotional stress condition based on the heart rate variability in rats. Methods. The model of immobilization stress, "open field" test, EEG, ECG, stereotactic method, histology methods, nonlinear analysis of EEG, heart rate variability analysis, statistical analysis. Theoretical and practical results, novelty. The ranges of KSe values of the EEG signal in rats during quiet wakefulness and in conditions of acute and long emotional stress have been established. An increased KSe was found in cortical areas of the left hemisphere and in the midbrain reticular formation in conditions of acute emotional stress. The absence of locomotor activity was reflected in the significant decrease of KSe in the right sensorimotor cortex. The stable increase in KSe in the conditions of free behavior after prolonged immobilization was observed. KSe was reduced under immobilization conditions on the background of chronic emotional stress. A decrease in heart rate variability, a decrease in total spectral power and the power in all frequency ranges as a result of the immobilization were observed. The area of application. Research of emotional stress mechanisms, lecture course of physiology.