Moskalets T. Energy of isometric contraction of skeletal muscle of white rats by experimental hypothyroidism and andrenergic stimulating (reseach in situ).

In thesis during complex reseach of muscle contraction parameters is shown that deep hypothyroidism (thyroidectomy) changes qualitatively the energy of contraction act what shown in main indices changes of as ergothrope so thermogenic function. It was determined that experimental hypothyroidism prolongated considerably (to 95%) latent period of isometric contraction of anterior tibial muscle of white rat, development of contraction act and increased time parameter of mounting maximum quantity of isometric tension (to 37%), independently from studying model of isometric act. It was shown that thermogenic value of isometric muscle contraction (+DТоС/Н.) during developing of tiresomeness decreased primary and then increased steadily. After thyroid gland elimination thermal value of isometric tension of skeletal muscle unit (H) primary higher as control level (+47%) and during developing of tiresomeness decreased at first (-31%) and then increased again (+45%). During the experiments in situ it was determined that hypothyroidism weaked considerably stimulative effect of adrenalin on important ergotropic parameters of isometric contraction of tibial muscle of white rats - maximum strength of contraction, time of its developing and latent period of contraction act. During andrenergic stimulation the increasing of thermal value of muscle contraction is ofserved, although with thyroidectomic animals it is increased considerably (to 41%), that shown increasing of energetic value unit of isometric "work" in case of thyroid sland elimination from hormone system of organism.