Nebesna Z. Kidney morphofunctional condition in terms of early necrectomy and lyophilized xenodermografts usage under experimental thermal trauma

This work is devoted to studing of kidney structural reorganization under experimental thermal trauma condition in terms of early necrectomy of injured skin parts and lyophilized xenodermografts usage. In an experiment on guinea pigs it was found that severe burn trauma causes considerable structural changes of all kidney’s components. Masometrical, macrometrical, hystological, morphometrical, biochemical investigations showed that character and level of the organ morphofunctional damages are not the same at different periods of thermal trauma. Adaptative – compensatory processes are gradually replaced by destructive changes of kidney vascular system, and all nephron components, which testifies about disorder of urine production. Revealed changes are developing on a background of increased blood plasma toxicity, high level of endogenic intoxication, rised concentration of urea and creatynin.