Kravchenko S. The polycystic kidney disease in domestic cats (pathogenesis, diagnostic and therapy)

Object of research - kidneys diseases of cats. The purpose of research - to investigate the functional condition of kidneys with polycystic kidneys disease in domestic cats, to define the informatively of clinical, biochemical and instrumental methods of its diagnosis and to determine experimentally the treatment efficiency of sick animals. Methods of research: clinical; biochemical: determination in urine urea, creatinine; in blood serum - total protein, urea, creatinine, potassium, sodium, activity of alkaline phosphatase; ultrasonografic; computer-tomographic, pathomorphological; the method of reproduction of full-scale model of arterial system of small animals kidneys; methods of statistic analysis. Scientific novelty of work: for the first time as a result of complex laboratory and instrumental investigations important links of pathogenesis of polycystic kidney disease in domestic cats have been found, particularly, the destruction of filtrative and concentrative kidneys functions, the disease complications - pyelonephritis and chronic kidneys insufficiency. On the basis of determinations the limits of separate biochemical indices of blood serum and urine we got the characteristics of polycystic kidney disease stages, which gave us the opportunity to diagnose and cure the sick animals. For the first time here was described the ultrasonografic characteristic of cats kidneys at various stages of polycystic kidney disease and revealed the link between clinical, ultrasonografic and biochemical indices. It was proved that is the polycystic kidney disease pathogenesis the growth of arterial length with simultaneous decrease of their diameter and total quantity of arched arteries has great influence, which is followed by the disturbance of hemodynamic in glomerulas atrophic and sclerotic changes in all kidneys structural components. It is offered: methods of reproduction of full-scale model of arterial system of small animals kid-neys (pathent of Ukraine in the useful model № 37020, to 10 november 2008). It is introduced: obtained results are used in scientific investigations and educational process, at studying as "The clinical diagnostic" and "Internal diseases of animals" (Poltava State Agrarian Academy), "The clinical diagnostic", "The clinical biochemistry" and "Internal diseases of animals" (Kharkiv State Zooveterinary Academy), "The clinical diagnostic of animals diseases" and "Internal diseases of animals" (National University of bioresourses and nature use of Ukraine) and in vet-erinary practice (Poltava city veterinary clinic). Results researching work were include in "Recommendation of diagnostics of polycystic kidney disease in domestic cats" Field of application: Veterinary Medicine.