Rolik S. Development of composition, technology and investigation of combined stomatological gel

Objects - preparation "Sonident" as gel for application in stomatology practice, tincture of sofora Japanese, nimesulid, gels bases; aim - development in theory and the experimentally grounded composition, technology and methods of control quality soft medicinal form as stomatology gel with tincture of sofora Japanese and nimesulid for a prevention and treatment inflammatory diseases of parodont; methods - organoleptical, pharmaco-technological (determining size of nimesulid particles), physical (potentiometer determination of pH, osmotic activity, structurally-mechanical descriptions etc) and chemical, byopharmacutical, microbiological (method of diffusion in agar, microbiological cleanness), biological (determination of optimum concentrations operating matters, study of specific activity and safety of the developed experimental standards), mathematical statistics (treatment of the experimentally got results); novelty - theoretical grounded and experimentally developed composition and rational technology of soft medical form, studied indexes of quality the offered medication, methods of authentication and quantitative determination operating matters are developed, studied stability of preparation in the process of storage, biological researches are set high anti-inflammatory, antimicrobial, reparative, woundhealing action of the developed stomatological gel; results -created and offered for practical medicine new original domestic medication as gel, the project of technological industrial regulation, analytical normative documentation, technological instruction are developed, gel technology is approved in the conditions of pharmacies and enterprises productions, results are inculcated in the educational process of six high educational institutes of Ukraine; area - pharmacy.