Kolot N. Іndices of carbohydrate metabolism in rabbits with experimental diabetes mellitus after transplantation of pancreatic is-lets into various tissues of the organism

The object of study - pancreatic islets of neonatal piglets and rabbits in vitro and during transplantation into various tissues of the organism of rabbits with experimental diabetes mellitus. Purpose - to study tissues specific influence of allo- and xenotransplantation of pancreatic Islets of neonatal animals on indices of carbohydrate metabolism in rabbits with experimental diabetes mellitus; to evaluate functional condition of organs of animals-recipients during the post-transplantation period. Methods: transplantation of pancreatic islets, light and fluorescence microscopy, immunoenzy-matic, radioimmunological, spectrophotometric methods, cytofluorymetric, histochemical, histological analysis. Theoreti-cal and practical results, novelty: prolonged reduction of glucose content in blood to normal rate and partial restoration of endocrine tissue of pancreas have been observed in rabbits after transplantation of the pancreatic islets of neonatal ani-mals into the spleen and portal vein. Transplantation of pancreatic islets of neonatal animals into liver parenchyma, under the renal capsule, into testis, into bone marrow was accompanied by short-term decrease of glucose level in the blood of animals-recipients. It has been proven that intraportal and intrasplenic transplantation of pancreatic islets of neonatal pig-lets has not caused any complications and has facilitated the recovery from metabolic disorders in organism of animals-recipients. Field of application: physiology of human and animals, endocrinology, transplantology.