Kovalchuk A. Hemomicrocirculatory bed of a stomach in norm and under action methyl tertiary butyl ether in experiment for rats

In the dissertation hemomicrocirculatory stomach beds of the rats were studied in norm and under action of different doses (500 mg/kg; 50 mg/kg; 5 mg/kg; 0.5 mg/kg) of methyl tertiary butyl ether. The topographical stratification of hemomicrocirculatory bed of mucous membrane of rat's stomach was established. The mosaic changes of hemomicrocirculatory vessels under action of methyl tertiary butyl ether occur in two steps: 1 - reactive and necrotic changes; 2 - changes of apoptosis. For the first time it was determined that combinatory damage of two histamine-producting cells in mucous membrane stomach's fundus (mast cells and ECL-cells) was a result of methyl tertiary butyl ether's toxic effect that triggered structural changes in hemomicrocirculatory beds, in cells of connective tissue and in epithelium of stomach mucous membrane.