Dmitrenko N. Glomerulonephritis in domestic cats (pathogenesis, diagnosis & therapy)

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0409U005841

Applicant for

Specialization

  • 16.00.01 - Діагностика і терапія тварин

17-12-2009

Specialized Academic Board

Д 27.821.02

Essay

The subject of investigation - kidney diseases in small animals. The object of investigation - to ascertain some links of pathogenesis & glomerulonephritis in domestic cats, the informative volumes of clinical, laboratory & instrumental methods of diagnosis, to work out the effective therapy schema. The methods of investigation - general clynical ones (examination, palpation, thermometria, auscultation); laboratory ones (the haemoglobin, erytrocytes & leucocytes quantity, SSE, leucogramme, general albumen & its fractions, the AsAT & AlAT activity, urea, creatininum, inorganic phosphorus, general calcium, glucose, chlorides, cholestyrol, general lipids, в-lypoproteins); physical & chemical urine analyses (colour, transparancy, consistation, smell, thickness, urea, creatininum, albumen,glucose, pH quantity, bilirubin, indican, blood & its fragments, ketonine bodies), microscopic investigation of urine sediment, histological, ultrasonographic methods of statistical analysis. Scientific novelty: for the first time were conducted the complex investigations of kidney functional condition in domestic cats & the urination system in the case of glomerulonephritis disease. The specifications of kidney vascular system branching with glomerulonefritis. For the first time the meaningness of haemerenal indeces was calculated & clinically confirmed which characterises the kidney general functions in cats suffering from glomerulonephritis, taking into account the daily urination. The methods of kidney filtration, concentration & reabsorbtion functions ascertaintion has been proposed on the basis of blood & urine indeces investigation & on the haemerenal indeces of cats suffering from glomerulonephritis. The link between clinical, ultrasonographic & biochemical indeces has been investigated. On the basis of blood & urine indeces research the efficiency of intravenous cifran injections has been proved. Proposed: "The way of full-scale model of small animals kidney system creation" (the patent of Ukraine for the useful model №37020 from November, 10, 2008). Introduced: The research results are used in scientific work & while teaching the subjects "Clinical Diagnosis", "Clinical Biochemistry" & "Animals Internal Diseases" in Poltava State Agrarian Academy, "Clinical Biochemistry" in Charkov State Zooveterinary Academy, "Animals Internal Diseases" in National University of bioresourses and nature use of Ukraine. The methodological recommendations about domestic cats nephritis diagnosis have been published. They were confirmed by the board of veterinary medicine general control in Poltava region (the record of proceedings №9, July, 4 2008). The branch of usage: veterinary medicine.

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