The investigation object: structural characteristics of the reorganization of tissue and dynamics of chemical composition of pancreas of mature laboratory malerats under the conditions of influence of different combinations of salts of heavy metals. The investigation goal: to determine appropria tenesses of morphological and readaptative changes in pancreas of mature laboratory malerats under influence of different combinations of salts of heavy metals (zinc, copper, iron; manganese, lead, copper; zinc, lead, chromium), and also results of correction of the revealed changes by preparation “Glutargin”. Methods of research: morphometry of mass and volume of pancreas, microscopy of pancreatic tissue, morphometry of hystopreparations, electronic microscopy of cells, quantitative estimation of indexes of chemical composition (spectrophotometry) of pancreas, statistic proceeding of the numerical data. Theoretical and practical value of the obtained results. The research allowed us to study morphological changes of tissue of pancreas and possibilities of its regeneration after influence of salts of heavy metals which contain in surplus amount in water and soil of Sumy region. Obtained experimental results may be assumed as morphological basis for prognostication of changes in organ and used in functional anatomy of digestive system, therapy, gastro-enterology, endocrinology. Possibility of reparative changes in pancreas at usage of metabolic preparation “Glutargin” is proved. Scientific novelty of the obtained results: basic appropriatenesses of morphological changes of pancreas under influence of different combinations of salts of heavy metals on the organism; disorders in pancreas on subcellular level at designed ecological factors of Sumy region; rate of accumulation of exogenous microelements in tissues of pancreas on different terms of subacute experiment were determined; dependence of structural changes of the organ on combination of salts of heavy metals was revealed; readaptative changes were studied and possibility of preparation “Glutargin” for stimulation of reparative processes in pancreas at conditions of technogenous microelementosises were grounded for the first time on experimental material by the use of complex of morphological methods of research. The degree of implementation: the results of experimental researches were introducted into educational process in higher educational institutions of Ukraine (Dnipropetrovsk State Medical Academy, Crimea State Medical University, Ternopil State Medical University, Vinnitsa State Pirogov Memorial Medical University, Bukovinian State Medical University, HSEI “Ukrainian Medical Stomatological Academy”, Lugansk State Medical University, medical faculty of Uzhhorod National University, medical institute of Sumy State University).
