Grigorova M. Antioxidant activity in various tissues of rats after prolonged exposure to ionizing radiation and heavy metals complex

The dissertation is devoted to the study of antioxidant activity in various tissues of rats in the conditions of the radiation-chemical exposure, and the possibility of using bee pollen to correct the effects of this exposure. It has been established that ionizing radiation and heavy metals because of long-term exposure evoke inhibition of the activity of the components of antioxidant protection in all the investigated brain regions. According to the indicators of overall antioxidant activity among the brain structures the cerebral cortex is the most resistant to radiation, and among the internal organs the heart is. The liver is the most damaged on account of heavy metals activity. It has been shown that the long-term influence of the applied radiation-chemical factors on the antioxidant system of the investigated tissues is not characterized by the additivity of the effects of these factors but shows complicated character of interaction between the processes that form appropriate response of an organism to the activity of various factors. It has also been established that under the impact of radiation-chemical factors the changes of the parameters of the antioxidant activity in tissues of the internal organs correlate with those ones in the cerebral cortex and subcortical regions of the brain. It has been revealed that the use of bee pollen in the background of the individual and combined effects of long-term radiation-chemical factors leads to the approximation of antioxidant activity in all the investigated organs and parts of the brain of rats to control values.