Kalyuzhnaya O. Composition and technology of the suppositories with probiotics

Dissertation is devoted development of composition and technology of the suppositories with probiotics. On the basis of complex researches composition of suppositories under the conditional name "Probiovagum", that contains the probiotic biomass lacto- and bifidobakterea and lactic acid, is offered. Suppositories base and excipient, that provides the best release of active components, is experimentally grounded. Technology of making of suppositories with probiotics is developed. The indicators of quality of suppositories are studied; it is found, that suppositories are stable for 1 years of storage at temperature of 8 °С to 15 °С. The projects of AND and technological industrial rules are developed. Specific activity of the preparation is established in conditions in vitro. The absence of toxic effect of the preparation is proved in conditions in vivo