Volkogon A. Morphological changes in lung caused by industrial microelementosis (anatomical experimental research).

The investigation object: a reconstruction of lung tissue, morphogenesis of alveole and ultrastructural parts of lung epithelial barrier, dynamics of chemical lung composition in rats of different ages in norm and under the conditions of influence of different combinations of salts of heavy metals. The investigation goal: to determine a regularity of lung structural changes on micro, macro and ultrastructural level, changes of it chemical composition under the conditions of influence of different combinations of salts of heavy metals in rats of different ages and determine the correction possibility of morphological changes with Emoxipin. Methods of research: lung, alveole and components of lung epithelial barrier morphometry, electronic and light microscopy of common lung morphological reaction, morphometry of hystopreparations quantitative estimation of indexes of chemical composition of lung, statistic proceeding of the numerical data. Theoretical and practical value of the obtained results. The research allowed to determine a peculiaruty of influence way of different combinations of salts of heavy metals on animal lung structure of different ages. Regularity of ages changes as an answer for polutant influence may be used for specific way in choosing of treatment and prophilactic of lung disease. Obtained experimental results may be assumed as morphological basis for prognostication of changes in lung and used in therapy, pulmonology, phtisiatry, pediatry, gerontology, ecology. For the first time on the experimental material, on the base of modern methods of investigations the peculiarity of chemical composition and rats lung structure of different aged groups under influence of different combi-nations of salts of zinc, copper, iron; manganese, lead, chromium in subacute experiment was investigated. The rebuilding of alveole and lung epithelial barrier to the direction to emphisemae and pheumosclerosis was determined. For the first time an influence of Emoxipin on morphofunctional condition of respiratory part of lung under influence of different combinations of salts of heavy metals was determined. It was revealed a high efficacy of the remedy and possibility of it using for profilactic and treatment of lung complications under influence of eksopolutants in condition of alimentar entering. The degree of implementation: the results of experimental researches were introducted into educational process and scientific work in department of human anatomy and department of general and operative surgery with topographic anatomy, traumatology and orthopedy Ternopol state medical university by I.J.Gorbachevsky, department of human anatomy of Vinitsa national medical university, department of human anatomy and histology of medical faculty of Uzhgorod national university, department of human anatomy of Bukovina state medical university.