Zadorozhnia V. Changes of the content of zinc in somatic cells under the conditions of alcohol action on the organism

The thesis is devoted to the investigation of changes of the content of zinc, copper and magnesium in somatic cells of humans and rats as a result of acute and chronic alcoholization. It is shown that alcohol significantly affects the content of zinc, copper and magnesium in granulocytes of blood and cells of zinc-depositing organs (hippocampus, insulocytes, Paneth cells, and prostate) that is manifested in accumulation of zinc in cells as a result of acute alcoholization and its depletion as a result of chronic use of alcohol. Alcoholization led to an increase of the amount of secretory products in cells of zinc-depositing organs, and changes in its content correlated with changes of the amount of zinc in those cells. Acute alcoholization activated the hypophyseal-adrenal system in contradistinction to chronic alcoholization that inhibited its activity. Experimental stress modeling by synthetic analogues of stress hormones (ACTH, adrenaline, prednisolone) and introduction of an antagonist of adrenaline (pilocarpine) is accompanied by differently directed changes of the content of zinc in granulocytes of blood and somatic cells of zinc-depositing organs: introduction of stress-hormones increased the content of zinc in cells while pylocarpin helped to reduce the content of zinc. Unidirected coupling changes of the content of zinc and secretory products in insulocytes and granulocytes of all modeled conditions are determined. High efficiency of pharmaceutical preparations of zincteral and cuprenil for correction of changes of the content of zinc, copper and magnesium under the conditions of chronic alcoholization is experimentally proved. The above mentioned preparations brought the content of these metals to the normal indices in cells and extracecullar space.