Vazhnenko O. Influence of anthropogenically loaded atmospheric air on zinc metabolic cells of human and animals

Thesis is dedicated to research of the early metabolic changes at cellular level of residents of metallurgical centres and association of such changes with regional characteristics of industrial air pollution in their respective regions. This work is greatly contributing to study of physiological role of zinc, especially in development of non specific adaptive syndrome of the cell system. Based on earlier ecological-hygienic analysis quality of atmospheric air different regions city of Zaporizhzhia and with use of modern cytochemical methods been carried out research of influence unfavorable ecological factors, particularly different levels of atmospheric air technogenic load on process of zinc accumulation in cells. Also been investigated connection between changes of zinc and copper cations content in neutrophilic granulocytes of humans and animals under influence unfavourable ecological factors of the environment. In result of completed experiments been established that prolonged influence of unfavourable ecological factors, especially polluted atmospheric air , can create deficit of zinc and secretory material, and can lead to accumulating copper cations in the cells. Established cells changes can be classified as symptoms of non-specific adaptive syndrome of cell system Key words: zinc, non-specific adaptive syndrome of the cell system, granulocytes, copper, air, polluters.