Shaymardanova L. The age-related morphologic and functional changes of bone marrow after the xenogenous cerebrospinal fluid exposure.

The dissertation is devoted to the study and revealing of morphological and functional changes of bone marrow after the xenogenous cerebrospinal fluid (XCSF) exposure. Research object: morphogenesis of haemocytopoetic organs after exogenous factors exposure. The aim of the research was to define in complex morphologic and functional age-related characteristics of rat bone marrow after parenteral infusion of XCSF. The research was conducted on 96 white Wistar rats. The morphological (morphometric, histomorphometric, cytomorphologic, cytochemical, electrone-microscopical) and statistical methods of material analysis were accomplished during the study. The results analysis has shown that the general vectors of XCSF influence on bone marrow and its rough stroma regardless of the animals' age and number od infusions, appeared the altering of the growth rate and shape formation of femurs, thickening of the bone compact matter, decrease of the yellow bone marrow volume, increase of the red one, induction of hemopoetic precursors, which resulted both in cellular renewal of the red bone marrow and complete differentiation of those cells. The scientific novelty of work is setting the fundamental theoretical base for understanding of processes of co-operation of haemocytopoetic modulating factors of donor in XCSF content with the recipient's own system of haemocytopoesis adjustment. The practical value of work lies in application of XCSF for stimulation of haemocytopoesis, and accordingly, induction of immunogenesis at dysplasia and aplasia syndromes of bone marrow, at immune depressions in the spheres of medicine and veterinary like haematology, oncohaematology, allergology, immune pathology. Presented concrete information can be taken into account, in a prospect, in technological developments during possible creation of multifunctional medicine of liquor origin.